Molecular Docking of Quinine Derivative as Inhibitor in Sars-Cov-2

Abstract The discovery of various new medicinal compounds from research clarifies the important role computational studies as initial basis for finding sources raw materials both natural and synthetic. SARS-coronavirus 2 (SARS-CoV-2) or COVID-19 is virus which responsible outbreak that affects almost entire world began in early 2020. This study aim to determine interaction between SARS-CoV-2 quinine derivative by utilizing developing plants ingredients, especially Corona antivirus. was conducted silico with molecular docking method. software used this AutodockVina. results showed 10 tested against cells, all ithas ability an antivirus binding affinity around -6 kcal / mol. native ligands have best among -7.9 also supported number hydrogen bondings bond lengths well.